Neuroimaging Detectable Differences between Parkinson's Disease Motor Subtypes: A Systematic Review.

ABSTRACT:

Background

The neuroanatomical substrates of Parkinson's disease (PD) with tremor-dominance (TD) and those with non-tremor dominance (nTD), postural instability and gait difficulty (PIGD), and akinetic-rigid (AR) are not fully differentiated. A better understanding of symptom specific pathoanatomical markers of PD subtypes may result in earlier diagnosis and more tailored treatment. Here, we aim to give an overview of the neuroimaging literature that compared PD motor subtypes.

Methods

A systematic literature review on neuroimaging studies of PD subtypes was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Search terms submitted to the PubMed database included: "Parkinson's disease", "MRI" and "motor subtypes"

SUBMITTER: Boonstra JT 

PROVIDER: S-EPMC7853198 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature