Altered central pain processing in fibromyalgia-A multimodal neuroimaging case-control study using arterial spin labelling.

ABSTRACT: Fibromyalgia is characterized by chronic pain and a striking discrepancy between objective signs of tissue damage and severity of pain. Function and structural alterations in brain areas involved in pain processing may explain this feature. Previous case-control studies in fibromyalgia focused on acute pain processing using experimentally-evoked pain paradigms. Yet, these studies do not allow conclusions about chronic, stimulus-independent pain. Resting-state cerebral blood flow (rsCBF) acquired by arterial spin labelling (ASL) may be a more accurate marker for chronic pain. The objective was to integrate four different functional and structural neuroimaging markers to evaluate the neural correlate of chronic, stimulus-independent pain using a resting-state paradigm. In line with the patho

SUBMITTER: Muller M 

PROVIDER: S-EPMC7853499 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature