Protocol for Measuring Compulsive-like Feeding Behavior in Mice.

ABSTRACT: Obesity is an important health problem with a strong environmental component that is acquiring pandemic proportion. The high availability of caloric dense foods promotes overeating potentially causing obesity. Animal models are key to validate novel therapeutic strategies, but researchers must carefully select the appropriate model to draw the right conclusions. Obesity is defined by an increased body mass index greater than 30 and characterized by an excess of adipose tissue. However, the regulation of food intake involves a close interrelationship between homeostatic and non-homeostatic factors. Studies in animal models have shown that intermittent access to sweetened or calorie-dense foods induces changes in feeding behavior. However, these studies are focused mainly on the final outcom

SUBMITTER: Fructuoso M 

PROVIDER: S-EPMC7854048 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature