Enhanced GABAergic Inhibition of Cholinergic Interneurons in the zQ175^+/- Mouse Model of Huntington's Disease.

ABSTRACT: Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that initially manifests itself in the striatum. How intrastriatal circuitry is altered by the disease is poorly understood. To help fill this gap, the circuitry linking spiny projection neurons (SPNs) to cholinergic interneurons (ChIs) was examined using electrophysiological and optogenetic approaches in ex vivo brain slices from wildtype mice and zQ175^+/- models of HD. These studies revealed a severalfold enhancement of GABAergic inhibition of ChIs mediated by collaterals of indirect pathway SPNs (iSPNs), but not direct pathway SPNs (dSPNs). This cell-specific alteration in synaptic transmission appeared in parallel with the emergence of motor symptoms in the zQ175^+/- model. The ada

SUBMITTER: Lim SAO 

PROVIDER: S-EPMC7854471 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature