Neurodevelopment in early treated HIV-infected infants participating in a developmental stimulation programme compared with controls.

ABSTRACT:

Background

Neurodevelopmental stimulation programmes can improve developmental outcomes. Antiretroviral therapy (ART) started soon after birth potentially limits the invasion of HIV into the central nervous system. A combination of developmental stimulation and early ART initiation may reduce developmental delays in children with perinatally acquired HIV infection.

Methods

At a single site in Johannesburg, South Africa, we enrolled 36 HIV-infected neonates on ART into an intervention group (IG) participating in a yearlong home-based, neurodevelopmental stimulation programme. Bayley Scales of Infant and Toddler Development-3rd Edition (BSID-III) assessments were conducted at 12 months. Scores were compared with 24 early treated HIV-infected infants in an observational group (

SUBMITTER: Strehlau R 

PROVIDER: S-EPMC7854479 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature