Moderation of the effect of glycemia on the risk of cardiovascular disease in type 1 diabetes: The DCCT/EDIC study.

ABSTRACT:

Aims

We assessed whether and to what extent established cardiovascular disease (CVD) risk factors moderate (enhance/reduce) the effect of hyperglycemia on CVD outcomes in the long-term follow-up of the Diabetes Control and Complications Trial type 1 diabetes (T1D) cohort (N = 1441).

Methods

Moderation of the effect of glycemia on subsequent risk of major adverse cardiovascular events (MACE: fatal or non-fatal myocardial infarction or stroke) and any-CVD (MACE plus confirmed angina, silent MI, revascularization, or congestive heart failure) was assessed separately using interaction terms between HbA1c and other risk factors in Cox proportional hazards models.

Results

Over a median follow-up of 29 years, there were 120 MACE cases and 239 any-CVD cases. Higher pulse, hig

SUBMITTER: Bebu I 

PROVIDER: S-EPMC7854481 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature