An update of cyclic nucleotide phosphodiesterase as a target for cardiac diseases.

ABSTRACT:

Introduction

Cyclic nucleotides, cAMP, and cGMP, are important second messengers of intracellular signaling and play crucial roles in cardiovascular biology and diseases. Cyclic nucleotide phosphodiesterases (PDEs) control the duration, magnitude, and compartmentalization of cyclic nucleotide signaling by catalyzing the hydrolysis of cyclic nucleotides. Individual PDEs modulate distinct signaling pathways and biological functions in the cell, making it a potential therapeutic target for the treatment of different cardiovascular disorders. The clinical success of several PDE inhibitors has ignited continued interest in PDE inhibitors and in PDE-target therapeutic strategies.

Areas covered

This review concentrates on recent research advances of different PDE isoforms with rega

SUBMITTER: Chen S 

PROVIDER: S-EPMC7854486 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature