Brain network reorganisation and spatial lesion distribution in systemic lupus erythematosus.

ABSTRACT:

Objective

This work investigates network organisation of brain structural connectivity in systemic lupus erythematosus (SLE) relative to healthy controls and its putative association with lesion distribution and disease indicators.

Methods

White matter hyperintensity (WMH) segmentation and connectomics were performed in 47 patients with SLE and 47 healthy age-matched controls from structural and diffusion MRI data. Network nodes were divided into hierarchical tiers based on numbers of connections. Results were compared between patients and controls to assess for differences in brain network organisation. Voxel-based analyses of the spatial distribution of WMH in relation to network measures and SLE disease indicators were conducted.

Results

Despite inter-individual di

SUBMITTER: Valdes Hernandez MDC 

PROVIDER: S-EPMC7854491 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature