Temporally distinct myeloid cell responses mediate damage and repair after cerebrovascular injury.

ABSTRACT: Cerebrovascular injuries can cause severe edema and inflammation that adversely affect human health. Here, we observed that recanalization after successful endovascular thrombectomy for acute large vessel occlusion was associated with cerebral edema and poor clinical outcomes in patients who experienced hemorrhagic transformation. To understand this process, we developed a cerebrovascular injury model using transcranial ultrasound that enabled spatiotemporal evaluation of resident and peripheral myeloid cells. We discovered that injurious and reparative responses diverged based on time and cellular origin. Resident microglia initially stabilized damaged vessels in a purinergic receptor-dependent manner, which was followed by an influx of myelomonocytic cells that caused severe edema. Prolo

SUBMITTER: Mastorakos P 

PROVIDER: S-EPMC7854523 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature