Evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment in age-related macular degeneration.

ABSTRACT: The purpose of this study was to quantitatively evaluate retinal pigment epithelium (RPE) changes in serous pigment epithelial detachment (PED) among patients with age-related macular degeneration by means of prototype multi-contrast optical coherence tomography (OCT), which is capable of simultaneous collection of OCT angiography, polarization-sensitive OCT, and standard OCT images. We evaluated 26 eyes of 21 patients with serous PED. RPE-melanin OCT images were calculated from the multi-contrast OCT dataset and compared with near-infrared autofluorescence images. An active RPE lesion was defined as an area of thickened RPE-melanin (≥ 70 μm; RPE₇₀) on RPE-melanin OCT. Each PED area was divided into peak and slope regions. RPE₇₀ area ratios were compared with the maxi

SUBMITTER: Miura M 

PROVIDER: S-EPMC7854605 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature