A new framework for MR diffusion tensor distribution.

ABSTRACT: The ability to characterize heterogeneous and anisotropic water diffusion processes within macroscopic MRI voxels non-invasively and in vivo is a desideratum in biology, neuroscience, and medicine. While an MRI voxel may contain approximately a microliter of tissue, our goal is to examine intravoxel diffusion processes on the order of picoliters. Here we propose a new theoretical framework and efficient experimental design to describe and measure such intravoxel structural heterogeneity and anisotropy. We assume that a constrained normal tensor-variate distribution (CNTVD) describes the variability of positive definite diffusion tensors within a voxel which extends its applicability to a wide range of b-values while preserving the richness of diffusion tensor distribution (DTD) paradigm un

SUBMITTER: Magdoom KN 

PROVIDER: S-EPMC7854653 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature