A metabolomic approach to target antimalarial metabolites in the Artemisia annua fungal endophytes.

ABSTRACT: Fungal endophytes are a major source of anti-infective agents and other medically relevant compounds. However, their classical blinded-chemical investigation is a challenging process due to their highly complex chemical makeup. Thus, utilizing cheminformatics tools such as metabolomics and computer-aided modelling is of great help deal with such complexity and select the most probable bioactive candidates. In the present study, we have explored the fungal endophytes associated with the well-known antimalarial medicinal plant Artemisia annua for their production of further antimalarial agents. Based on the preliminary antimalarial screening of these endophytes and using LC-HRMS-based metabolomics and multivariate analyses, we suggested different potentially active metabolites (compounds 1-8

SUBMITTER: Alhadrami HA 

PROVIDER: S-EPMC7854678 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature