Mechanotransduction via the coordinated actions of integrins, PI3K signaling and Connexin hemichannels.

ABSTRACT: Mechanical loading opens connexin 43 (Cx43) hemichannels (HCs), leading to the release of bone anabolic molecules, such as prostaglandins, from mechanosensitive osteocytes, which is essential for bone formation and remodeling. However, the mechanotransduction mechanism that activates HCs remains elusive. Here, we report a unique pathway by which mechanical signals are effectively transferred between integrin molecules located in different regions of the cell, resulting in HC activation. Both integrin α5 and αV were activated upon mechanical stimulation via either fluid dropping or flow shear stress (FSS). Inhibition of integrin αV activation or ablation of integrin α5 prevented HC opening on the cell body when dendrites were mechanically stimulated, suggesting mechanical transmission from

SUBMITTER: Riquelme MA 

PROVIDER: S-EPMC7854719 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature