Proteinuria Reduction and Kidney Survival in Focal Segmental Glomerulosclerosis.

ABSTRACT:

Rationale & objective

Remission of proteinuria has been shown to be associated with lower rates of kidney disease progression among people with focal segmental glomerulosclerosis (FSGS). The goal of this study was to evaluate whether reductions in proteinuria after treatment are associated with greater kidney survival.

Study design

Cohort analysis of clinical trial participants.

Setting & participants

Patients with steroid-resistant FSGS enrolled in a randomized treatment trial that compared cyclosporine with mycophenolate mofetil plus dexamethasone.

Predictors

Reduction in proteinuria measured during 26 weeks after initiating treatment.

Outcomes

Repeated assessments of estimated glomerular filtration rate (eGFR) and time to a composite outcome of kidney

SUBMITTER: Troost JP 

PROVIDER: S-EPMC7854818 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature