Leptin signaling in vagal afferent neurons supports the absorption and storage of nutrients from high-fat diet.

ABSTRACT:

Objective

Activation of vagal afferent neurons (VAN) by postprandial gastrointestinal signals terminates feeding and facilitates nutrient digestion and absorption. Leptin modulates responsiveness of VAN to meal-related gastrointestinal signals. Rodents with high-fat diet (HF) feeding develop leptin resistance that impairs responsiveness of VAN. We hypothesized that lack of leptin signaling in VAN reduces responses to meal-related signals, which in turn decreases absorption of nutrients and energy storage from high-fat, calorically dense food.

Methods

Mice with conditional deletion of the leptin receptor from VAN (Nav1.8-Cre/LepR^fl/fl; KO) were used in this study. Six-week-old male mice were fed a 45% HF for 4 weeks; metabolic phenotype, food intake, and energy exp

SUBMITTER: Huang KP 

PROVIDER: S-EPMC7854885 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature