High-Resolution Mapping of Transcription Initiation in the Asexual Stages of Toxoplasma gondii.

ABSTRACT: Toxoplasma gondii is a common parasite of humans and animals, causing life-threatening disease in the immunocompromized, fetal abnormalities when contracted during gestation, and recurrent ocular lesions in some patients. Central to the prevalence and pathogenicity of this protozoan is its ability to adapt to a broad range of environments, and to differentiate between acute and chronic stages. These processes are underpinned by a major rewiring of gene expression, yet the mechanisms that regulate transcription in this parasite are only partially characterized. Deciphering these mechanisms requires a precise and comprehensive map of transcription start sites (TSSs); however, Toxoplasma TSSs have remained incompletely defined. To address this challenge, we used 5'-end RNA seque

SUBMITTER: Markus BM 

PROVIDER: S-EPMC7854901 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature