Glycaemic markers and all-cause mortality in older adults with and without diabetes: the Atherosclerosis Risk in Communities (ARIC) study.

ABSTRACT:

Aims/hypothesis

There is controversy regarding the performance of HbA_1c in old age. We evaluated the prognostic value of HbA_1c and other glycaemic markers (fructosamine, glycated albumin, fasting glucose) with mortality risk in older adults (66-90 years).

Methods

This was a prospective analysis of 5636 participants (31% with diagnosed diabetes, mean age 76, 58% female, 21% black) in the Atherosclerosis Risk in Communities (ARIC) study, baseline 2011-2013. We used Cox regression to examine associations of glycaemic markers (modelled in categories) with mortality risk, stratified by diagnosed diabetes status.

Results

During a median of 6 years of follow-up, 983 deaths occurred. Among older adults with diabetes, 30% had low HbA_1c (<42 mmo

SUBMITTER: Rooney MR 

PROVIDER: S-EPMC7855037 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature