Inhibitory interneurons in a brainstem circuit adjust their inhibitory motifs to process multimodal input.

ABSTRACT:

Key points

Inhibitory-interneuron networks, consisting of multiple forms of circuit motifs including reciprocal (inhibitory interneurons inhibiting other interneurons) and feedforward (inhibitory interneurons inhibiting principal neurons) connections, are crucial in processing sensory information. The present study applies a statistical method to in vivo multichannel spike trains of dorsal cochlear nucleus neurons to disentangle reciprocal and feedforward-inhibitory motifs. After inducing input-specific plasticity, reciprocal and feedforward inhibition are found to be differentially regulated, and the combined effect synergistically modulates circuit output. The findings highlight the interplay among different circuit motifs as a key element in neural computation.

Abstract

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SUBMITTER: Wu C 

PROVIDER: S-EPMC7855092 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature