B-type natriuretic peptide and cardiac remodelling after myocardial infarction: a randomised trial.

ABSTRACT:

Objective

B-type natriuretic peptide (BNP) has favourable effects on left ventricular remodelling, including antifibrotic and antiapoptotic properties. We tested the hypothesis that infusion of BNP after an acute myocardial infarction would reduce left ventricular systolic and diastolic volumes and improve left ventricular ejection fraction compared with placebo.

Methods

A total of 58 patients who underwent successful revascularisation for an acute ST elevation anterior myocardial infarction were randomised to receive 72-hour infusion of BNP at 0.006 µg/kg/min or placebo. Left ventricular end diastolic and systolic volumes and left ventricular ejection fraction were measured at baseline and at 30 days by multigated acquisition scan. Left ventricular infarction size was measu

SUBMITTER: Hubers SA 

PROVIDER: S-EPMC7855133 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature