The impact of maternal obesity and breast milk inflammation on developmental programming of infant growth.

ABSTRACT:

Background

Little is known about how maternal obesity impacts breast milk (BM) composition and how BM composition may impact growth. We sought to determine the role of maternal body mass index (BMI) on BM inflammatory and oxidative stress markers and to delineate the role of these BM markers on infant growth.

Methods

This was a secondary analysis of 40 mother-infant dyads. We first assessed the association between maternal BMI and BM marker (omega-6:omega-3 polyunsaturated fatty acid ratio (n-6:n-3 PUFA), leptin, interleukin (IL)-8, IL-6, IL-1β and malondialdehyde (MDA)) concentration at one (V1) and four (V4) months postpartum. We then examined the association between BM markers on infant growth trajectory from birth to seven months.

Results

Higher maternal BMI was a

SUBMITTER: Enstad S 

PROVIDER: S-EPMC7855210 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature