A Systematic Review and Meta-Analysis of the Relationship Between Social Dominance Status and Common Behavioral Phenotypes in Male Laboratory Mice.

ABSTRACT: Background: Social dominance status (e.g., dominant or subordinate) is often associated with individual differences in behavior and physiology but is largely neglected in experimental designs and statistical analysis plans in biomedical animal research. In fact, the extent to which social dominance status affects common experimental outcomes is virtually unknown. Given the pervasive use of laboratory mice and culminating evidence of issues with reproducibility, understanding the role of social dominance status on common behavioral measures used in research may be of paramount importance. Methods: To determine whether social dominance status-one facet of the social environment-contributes in a systematic way to standard measures of behavior in biomedical science, we conducted

SUBMITTER: Varholick JA 

PROVIDER: S-EPMC7855301 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature