DNA methylation in children with prenatal methamphetamine exposure and environmental adversity.

ABSTRACT:

Background

Methamphetamine (MA) use during pregnancy is a significant public health concern in the United States and affects long-term brain and behavioral development in children. We hypothesized that prenatal MA exposure would be related to greater DNA methylation of HSD11B2 and postnatal environmental stress.

Methods

The Infant Development, Environment, and Lifestyle Study (IDEAL), a longitudinal study of prenatal MA exposure enrolled mother-infant dyads in California, Hawaii, Iowa, and Oklahoma. Prenatal exposure was defined by maternal self-report and/or meconium toxicology screening. At ages 10-11 years, 100 children were assessed for drug exposure and DNA methylation of HSD11B2. Hierarchical linear models were used to determine the association between prenatal MA expo

SUBMITTER: Oni-Orisan OO 

PROVIDER: S-EPMC7855315 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature