Family history of breast cancer in men with non-BRCA male breast cancer: implications for cancer risk counseling.

ABSTRACT:

Purpose

The role of genetic predisposition in male breast cancer (MBC) patients who test negative for a BRCA mutation is unclear. The aim of this study is to define the association between MBC and family history of breast cancer in patients without mutations in BRCA1 or BRCA2.

Methods

We conducted an unmatched case-control study with men who received commercial testing for germline mutations in cancer susceptibility genes, including 3,647 MBC cases who tested negative for deleterious mutations in BRCA1/BRCA2, and 4,269 men with a personal history of colorectal cancer who tested negative for mutations in DNA mismatch repair genes to serve as controls. Associations between family history of breast cancer and MBC were estimated using unconditional multivariable logistic regress

SUBMITTER: Calip GS 

PROVIDER: S-EPMC7855353 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature