Long-Term Cocaine Self-administration Produces Structural Brain Changes That Correlate With Altered Cognition.

ABSTRACT:

Background

An enduring question from cross-sectional clinical studies is whether the structural and functional differences often observed between cocaine users and healthy control subjects result from a history of drug use or instead reflect preexisting differences. To assess causality from drug exposure, true predrug baseline imaging and neurocognitive assessments are needed.

Methods

We addressed this fundamental question of causality using longitudinal anatomical magnetic resonance imaging and neurocognitive assessments in rhesus macaques. Cognitive tasks employed were stimulus reversal learning as a measure of cognitive flexibility/inhibitory control and delayed match to sample as a measure of visual working memory. Time points examined were before and following 12 months

SUBMITTER: Jedema HP 

PROVIDER: S-EPMC7855373 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature