Characterizing the effect of background selection on the polygenicity of brain-related traits.

ABSTRACT:

Background

Genome-wide association studies (GWAS) have demonstrated that psychopathology phenotypes are affected by many risk alleles with small effect (polygenicity). It is unclear how ubiquitously evolutionary pressures influence the genetic architecture of these traits.

Methods

We partitioned SNP heritability to assess the contribution of background (BGS) and positive selection, Neanderthal local ancestry, functional significance, and genotype networks in 75 brain-related traits (8411 ≤ N ≤ 1,131,181, mean N = 205,289). We applied binary annotations by dichotomizing each measure based on top 2%, 1%, and 0.5% of all scores genome-wide. Effect size distribution features were calculated using GENESIS. We tested the relationship between effect size distribution descriptive st

SUBMITTER: Wendt FR 

PROVIDER: S-EPMC7855394 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature