Vulnerable and Resilient Phenotypes in a Mouse Model of Anorexia Nervosa.

ABSTRACT:

Background

Increased physical activity is a common feature of anorexia nervosa (AN). Although high activity levels are associated with greater risk of developing AN, particularly when combined with dieting, most individuals who diet and exercise maintain a healthy body weight. It is unclear why some individuals develop AN while most do not. A rodent model of resilience and vulnerability to AN would be valuable to research. Dopamine, which is believed to play a crucial role in AN, regulates both reward and activity and may modulate vulnerability.

Methods

Adolescent and young adult female C57BL/6N mice were tested in the activity-based anorexia (ABA) model, with an extended period of food restriction in adult mice. ABA was also tested in dopamine transporter knockdown mice and

SUBMITTER: Beeler JA 

PROVIDER: S-EPMC7855473 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature