Bone metastases induce metabolic changes and mitophagy in mice.

ABSTRACT:

New findings

What is the central question of this study? Cachexia causes severe changes in skeletal muscle metabolism and function and is a key predictor of negative outcomes in cancer patients: what are the changes in whole animal energy metabolism and mitochondria in skeletal muscle? What is the main finding and its importance? There is decreased whole animal energy expenditure in mice with cachexia. They displayed highly dysmorphic mitochondria and mitophagy in skeletal muscle.

Abstract

Cachexia causes changes in skeletal muscle metabolism. Mice with MDA-MB-231 breast cancer bone metastases and cachexia have decreased whole animal energy metabolism and increased skeletal muscle mitophagy. We examined whole animal energy metabolism by indirect calorimetry in mice with MDA-

SUBMITTER: Wilcox-Hagerty J 

PROVIDER: S-EPMC7855482 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature