Cardiovascular Family History Increases Risk for Late-Onset Adverse Cardiovascular Outcomes in Childhood Cancer Survivors: A St. Jude Lifetime Cohort Report.

ABSTRACT:

Background

Survivors of childhood cancer have an increased risk of therapy-related cardiovascular disease. It is not known whether family history of cardiovascular disease further increases risk of adverse cardiovascular outcomes among survivors.

Methods

Family history of cardiovascular disease was collected from 1,260 survivors [median age at diagnosis, 8 years (range, 0-23); age at last follow-up, 35 years (range, 18-66)] of childhood cancer in the St. Jude Lifetime Cohort Study. Multivariable risk models evaluated associations with cardiovascular disease (Common Terminology Criteria for Adverse Events grade 2-4 events) and cardiovascular risk factors.

Results

Among survivors exposed to chest-directed radiation and/or anthracycline chemotherapy (n = 824), 7%

SUBMITTER: Goldberg JF 

PROVIDER: S-EPMC7855495 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature