A Critical Role for Na⁺/H⁺ Exchanger Regulatory Factor 1 in Modulating FcεRI-Mediated Mast Cell Activation.

ABSTRACT: Mast cells are tissue-resident immune cells that play pivotal roles in initiating and amplifying allergic/anaphylactic reactions in humans. Their activation occurs via multiple mechanisms, which include cross-linking of the IgE-bound, high-affinity IgE receptors (FcεRI) by allergens or Ags and the binding of anaphylatoxins such as C3a to its receptor, C3aR. We have previously demonstrated that the Na⁺/H⁺ exchanger regulatory factor 1 (NHERF1) promotes C3aR functions in human mast cells. In the current study, we show that NHERF1 regulates mast cell response following FcεRI stimulation. Specifically, intracellular Ca²⁺ mobilization, activation of the MAPKs (ERK1/2 and P38), and production of cytokines (IL-13 and IL-6) following exposure to IgE/Ag were signifi

SUBMITTER: Kammala AK 

PROVIDER: S-EPMC7855521 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature