Cortical thickness mediates the relationship between DRD2 C957T polymorphism and executive function across the adult lifespan.

ABSTRACT: Dopamine (DA) signaling is critical for optimal cognitive performance. Aging is accompanied by a change in the strength of this signaling, with a loss of striatal and extrastriatal D2 binding potential. The reduction in dopamine modulation with age negatively influences various aspects of cognition. DRD2 C957T (rs6277) impacts DA D2 receptor density and availability, with C homozygotes linked to lower striatal DA availability and reduced executive functioning (EF), but also high extrastriatal binding potential. Here, we investigated in 176 participants aged 20-94 years whether: (1) DRD2 C carriers differ from T carriers in cortical thickness or subcortical volume in areas of high concentrations of D2 receptors that receive projections from mesocortical or nigrostriatal dopaminergic pathway

SUBMITTER: Miranda GG 

PROVIDER: S-EPMC7855542 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature