SLAMF7 Signaling Reprograms T Cells toward Exhaustion in the Tumor Microenvironment.

ABSTRACT: T cell exhaustion represents one of the most pervasive strategies tumors employ to circumvent the immune system. Although repetitive, cognate TCR signaling is recognized as the primary driving force behind this phenomenon, and it remains unknown what other forces drive T cell exhaustion in the tumor microenvironment (TME). In this study, we show that activation of the self-ligand SLAMF7 immune receptor on T cells induced STAT1 and STAT3 phosphorylation, expression of multiple inhibitory receptors, and transcription factors associated with T cell exhaustion. Analysis of The Cancer Genome Atlas revealed that SLAMF7 transcript levels were strongly correlated with various inhibitory receptors and that high SLAMF7 expression was indicative of poor survival in clear cell renal cell carcinoma (cc

SUBMITTER: O'Connell P 

PROVIDER: S-EPMC7855551 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature