Race, APOL1 Risk Variants, and Clinical Outcomes among Older Adults: The ARIC Study.

ABSTRACT:

Background/objectives

APOL1 high-risk genotypes confer an increased risk for kidney disease, but their clinical significance among older adults remains unclear. We aimed to determine whether APOL1 genotype status (high risk = 2 risk alleles; low risk = 0-1 risk alleles) and self-reported race (Black; White) are associated with number of hospitalizations, incident chronic kidney disease (CKD), end-stage renal disease (ESRD), and mortality among older adults participating in a community-based cohort study.

Design

Observational longitudinal cohort study.

Setting

The Atherosclerosis Risk in Communities (ARIC) study.

Participants

Community-dwelling older adults (mean age = 75.8 years; range = 66-90 years).

Results

Among 5,564 ARIC participants (78.2% White, 1

SUBMITTER: Chen TK 

PROVIDER: S-EPMC7855571 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature