Aging of the immune system and impaired muscle regeneration: A failure of immunomodulation of adult myogenesis.

ABSTRACT: Skeletal muscle regeneration that follows acute injury is strongly influenced by interactions with immune cells that invade and proliferate in the damaged tissue. Discoveries over the past 20 years have identified many of the key mechanisms through which myeloid cells, especially macrophages, regulate muscle regeneration. In addition, lymphoid cells that include CD8+ T-cells and regulatory T-cells also significantly affect the course of muscle regeneration. During aging, the regenerative capacity of skeletal muscle declines, which can contribute to progressive loss of muscle mass and function. Those age-related reductions in muscle regeneration are accompanied by systemic, age-related changes in the immune system, that affect many of the myeloid and lymphoid cell populations that can influ

SUBMITTER: Tidball JG 

PROVIDER: S-EPMC7855614 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature