Group 2 innate lymphoid cells in nasal polyposis.

ABSTRACT:

Objective

Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by a chronic type 2 inflammatory response in the paranasal sinuses. Group 2 innate lymphoid cells (ILC2s) are potent innate immune cells that contribute to type 2 inflammation by producing cytokines such as interleukin (IL)-4, IL-5, and IL-13. There is increasing evidence suggesting that ILC2s play an important role in the CRSwNP pathogenesis.

Data sources

We reviewed published literature obtained through PubMed inquiries.

Study selections

Studies relevant to the presence, function, and activation of ILC2s in CRSwNP were included.

Results

Nasal polyps (NPs) are one of the first tissues in which human ILC2s were discovered, and many groups have since reported that these cells are highly

SUBMITTER: Stevens WW 

PROVIDER: S-EPMC7855639 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature