Age at menarche and risk of vasomotor menopausal symptoms: a pooled analysis of six studies.

ABSTRACT:

Objective

To examine the association between age at menarche and risk of vasomotor menopausal symptoms (VMS) and whether midlife body mass index (BMI) modified the association.

Design

A pooled analysis of six cohort studies.

Setting

The International collaboration on the Life course Approach to reproductive health and Chronic disease Events (InterLACE).

Population

18 555 women from the UK, USA and Australia.

Methods

VMS frequency data (never, rarely, sometimes and often) were harmonised from two studies (n = 13 602); severity data (never, mild, moderate and severe) from the other four studies (n = 4953). Multinominal logistic regression models were used to estimate relative risk ratios (RRRs) and 95% CIs adjusted for confounders and incorporated study as

SUBMITTER: Chung HF 

PROVIDER: S-EPMC7855657 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature