Effects of long-term vitamin D and n-3 fatty acid supplementation on inflammatory and cardiac biomarkers in patients with type 2 diabetes: secondary analyses from a randomised controlled trial.

ABSTRACT:

Aims/hypothesis

Interventions that reduce inflammation may delay progression of microvascular and macrovascular complications in diabetes. We examined the effects of vitamin D₃ and/or n-3 fatty acid supplementation vs placebo on 5 year changes in serum inflammatory and cardiac biomarkers in adults with type 2 diabetes.

Methods

This study reports pre-specified secondary outcomes of the Vitamin D and Omega-3 Trial to Prevent and Treat Diabetic Kidney Disease, in which 1312 US adults with type 2 diabetes and without known cardiovascular disease, malignancy, or end-stage kidney disease were randomised using computer-generated random numbers in blocks of eight to vitamin D₃ (2000 IU/day) vs placebo and n-3 fatty acids (eicosapentaenoic acid [EPA] and docosah

SUBMITTER: Limonte CP 

PROVIDER: S-EPMC7855668 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature