Beyond PD-MCI: objectively defined subtle cognitive decline predicts future cognitive and functional changes.

ABSTRACT:

Objective

Cognitive impairment is prevalent among individuals with Parkinson's disease (PD). Effort has been made to identify individuals at risk for cognitive decline and dementia. Objectively-defined subtle cognitive decline (Obj-SCD) is a novel classification that may identify individuals at risk for cognitive decline prior to a diagnosis of mild cognitive impairment (MCI). We examined the utility of Obj-SCD criteria to predict future cognitive decline and difficulties with activities of daily living (ADLs) among individuals with PD.

Method

The sample included 483 individuals newly diagnosed with PD. Participants were followed for a five-year span with yearly visits where they completed neuropsychological tests. Participants were categorized as cognitively normal (CN), th

SUBMITTER: Jones JD 

PROVIDER: S-EPMC7855683 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature