Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture.

ABSTRACT: Linker histone H1 proteins bind to nucleosomes and facilitate chromatin compaction¹, although their biological functions are poorly understood. Mutations in the genes that encode H1 isoforms B-E (H1B, H1C, H1D and H1E; also known as H1-5, H1-2, H1-3 and H1-4, respectively) are highly recurrent in B cell lymphomas, but the pathogenic relevance of these mutations to cancer and the mechanisms that are involved are unknown. Here we show that lymphoma-associated H1 alleles are genetic driver mutations in lymphomas. Disruption of H1 function results in a profound architectural remodelling of the genome, which is characterized by large-scale yet focal shifts of chromatin from a compacted to a relaxed state. This decompaction drives distinct changes in epigenetic states, primarily owing

SUBMITTER: Yusufova N 

PROVIDER: S-EPMC7855728 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature