A novel method of donor‒recipient size matching in pediatric heart transplantation: A total cardiac volume‒predictive model.

ABSTRACT:

Background

The pediatric heart transplant community uses weight-based donor-to-recipient size matching almost exclusively, despite no evidence to validate weight as a reliable surrogate of cardiac size. Donor size mismatch is the second most common reason for the refusal of donor hearts in current practice (∼30% of all refusals). Whereas case-by-case segmentation of total cardiac volume (TCV) by computed tomography (CT) for direct virtual transplantation is an attractive option, it remains limited by the unavailability of donor chest CT. We sought to establish a predictive model for donor TCV on the basis of anthropomorphic and chest X-ray (CXR) cardiac measures.

Methods

Banked imaging studies from 141 subjects with normal CT chest angiograms were obtained and segmented usin

SUBMITTER: Szugye NA 

PROVIDER: S-EPMC7855742 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature