Coordinate Regulation of Ribosome and tRNA Biogenesis Controls Hypoxic Injury and Translation.

ABSTRACT: The translation machinery is composed of a myriad of proteins and RNAs whose levels must be coordinated to efficiently produce proteins without wasting energy or substrate. However, protein synthesis is clearly not always perfectly tuned to its environment, as disruption of translation machinery components can lengthen lifespan and stress survival. While much has been learned from bacteria and yeast about translational regulation, much less is known in metazoans. In a screen for mutations protecting C. elegans from hypoxic stress, we isolated multiple genes impacting protein synthesis: a ribosomal RNA helicase gene, tRNA biosynthesis genes, and a gene controlling amino acid availability. To define better the mechanisms by which these genes impact protein synthesis, we performed a second sc

SUBMITTER: Itani OA 

PROVIDER: S-EPMC7855744 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature