Uncovering Outcome Disparities of β₂ Adrenergic Agonists in Blacks: A Systematic Review.

ABSTRACT:

Purpose

Outcome differences driven by variation in Blacks' biologic response to treatment may contribute to persistent racial disparities in asthma morbidity and mortality. This review assessed systematic variation in β₂ agonist treatment outcomes among Blacks compared to other groups.

Methods

We conducted a systematic review of studies reporting differential response to β₂ agonists among Blacks, including studies identifying pharmacogenetic variants.

Results

Of 3158 papers, 20 compared safety or efficacy of β₂ agonists among Blacks as compared with other subgroups. Six papers evaluating efficacy of short-acting β₂ agonists (SABA) found similar or improved results among Blacks compared with other groups, while one small stud

SUBMITTER: Jerome RN 

PROVIDER: S-EPMC7855752 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature