Genetically predicted circulating protein biomarkers and ovarian cancer risk.

ABSTRACT:

Objective

Most women with epithelial ovarian cancer (EOC) are diagnosed after the disease has metastasized and survival in this group remains poor. Circulating proteins associated with the risk of developing EOC have the potential to serve as biomarkers for early detection and diagnosis. We integrated large-scale genomic and proteomic data to identify novel plasma proteins associated with EOC risk.

Methods

We used the germline genetic variants most strongly associated (P <1.5 × 10^-11) with plasma levels of 1329 proteins in 3301 healthy individuals from the INTERVAL study to predict circulating levels of these proteins in 22,406 EOC cases and 40,941 controls from the Ovarian Cancer Association Consortium (OCAC). Association testing was performed by weighting the be

SUBMITTER: Considine DPC 

PROVIDER: S-EPMC7855757 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature