Monocyte activation in persons living with HIV and tuberculosis coinfection.

ABSTRACT:

Objectives

To characterize monocyte subsets and activation in persons living with HIV (PLWH) with tuberculosis coinfection.

Design

Cross-sectional study within a cohort of PLWH and HIV-uninfected participants at the Joint Clinical Research Centre in Kampala, Uganda.

Methods

Participants were at least 45 years old with at least one cardiovascular risk factor. PLWH had an HIV viral load 1000 copies/ml or less on stable antiretroviral therapy prior to cohort entry. QuantiFERON-TB testing was performed to define latent tuberculosis infection (LTBI). Prior active TB was defined by self-report and verified by medical records. Blood was stained with monocyte subset markers (CD14+, CD16), CD62p, CD69, CX3CR1, HLA-DR, and tissue factor, and examined with flow cytometry.

Res

SUBMITTER: Huaman MA 

PROVIDER: S-EPMC7855758 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature