Application of high-resolution metabolomics to identify biological pathways perturbed by traffic-related air pollution.

ABSTRACT:

Background

Substantial research has investigated the adverse effects of traffic-related air pollutants (TRAP) on human health. Convincing associations between TRAP and respiratory and cardiovascular diseases are known, but the underlying biological mechanisms are not well established. High-resolution metabolomics (HRM) is a promising platform for untargeted characterization of molecular mechanisms between TRAP and health indexes.

Objectives

We examined metabolic perturbations associated with short-term exposures to TRAP, including carbon monoxide (CO), nitrogen dioxide (NO₂), ozone (O₃), fine particulate matter (PM_2.5), organic carbon (OC), and elemental carbon (EC) among 180 participants of the Center for Health Discovery and Well-Being (CHD

SUBMITTER: Li Z 

PROVIDER: S-EPMC7855798 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature