Smoking Accelerates Atrioventricular Conduction in Humans Concordant with Increased Dopamine Release.

ABSTRACT: Smoking is associated with cardiac arrhythmia, stroke, heart failure, and sudden cardiac arrest, all of which may derive from increased sympathetic influence on cardiac conduction system and altered ventricular repolarization. However, knowledge of the effects of smoking on supraventricular conduction, and the role of the sympathetic nervous system in them, remains incomplete. Participants with intermediate-high cardiovascular disease risk were measured for urinary catecholamines and cotinine, and 12-lead electrocardiograms (ECGs) were measured for atrial and atrioventricular conduction times, including P duration, PR interval, and PR segment (lead II), which were analyzed for associations with cotinine by generalized linear models. Statistical mediation analyses were then used to test whe

SUBMITTER: Irfan AB 

PROVIDER: S-EPMC7855806 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature