Stimulation of the right entorhinal white matter enhances visual memory encoding in humans.

ABSTRACT:

Background

While deep brain stimulation has been successful in treating movement disorders, such as in Parkinson's disease, its potential application in alleviating memory disorders is inconclusive.

Objective/hypothesis

We investigated the role of the location of the stimulating electrode on memory improvement and hypothesized that entorhinal white versus gray matter stimulation would have differential effects on memory.

Methods

Intracranial electrical stimulation was applied to the entorhinal area of twenty-two participants with already implanted electrodes as they completed visual memory tasks.

Results

We found that stimulation of right entorhinal white matter during learning had a beneficial effect on subsequent memory, while stimulation of adjacent gray mat

SUBMITTER: Mankin EA 

PROVIDER: S-EPMC7855810 | biostudies-literature | 2021 Jan-Feb

REPOSITORIES: biostudies-literature