Autophagy Regulation and Photodynamic Therapy: Insights to Improve Outcomes of Cancer Treatment.

ABSTRACT: Cancer is considered an age-related disease that, over the next 10 years, will become the most prevalent health problem worldwide. Although cancer therapy has remarkably improved in the last few decades, novel treatment concepts are needed to defeat this disease. Photodynamic Therapy (PDT) signalize a pathway to treat and manage several types of cancer. Over the past three decades, new light sources and photosensitizers (PS) have been developed to be applied in PDT. Nevertheless, there is a lack of knowledge to explain the main biochemical routes needed to trigger regulated cell death mechanisms, affecting, considerably, the scope of the PDT. Although autophagy modulation is being raised as an interesting strategy to be used in cancer therapy, the main aspects referring to the autophagy ro

SUBMITTER: Martins WK 

PROVIDER: S-EPMC7855851 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature