Markers of cholesterol synthesis are elevated in adolescents and young adults with type 2 diabetes.

ABSTRACT:

Background

Changes in cholesterol absorption and cholesterol synthesis may promote dyslipidemia and cardiovascular disease in individuals with type 2 diabetes mellitus (T2DM).

Objective

To assess cholesterol synthesis and absorption in lean individuals, obese individuals, and individuals with T2DM.

Methods

We measured lathosterol and lanosterol (markers of cholesterol synthesis) as well as campesterol and β-sitosterol (markers of cholesterol absorption) in the serum of 15 to 26 years old individuals with T2DM (n = 95), as well as their lean (n = 98) and obese (n = 92) controls.

Results

Individuals with T2DM showed a 51% increase in lathosterol and a 65% increase in lanosterol compared to lean controls. Similarly, obese individuals showed a 31% increase in latho

SUBMITTER: Semova I 

PROVIDER: S-EPMC7855867 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature