Persistent organic pollutants and maternal glycemic outcomes in a diverse pregnancy cohort of overweight women.

ABSTRACT:

Background

Animal and human studies suggest certain persistent organic pollutants (POPs) may impact glucose metabolism; however, few epidemiologic studies have examined environmental determinants of glycemic outcomes during pregnancy. Our objective is to evaluate associations between exposures to individual and mixture of POPs and measures of prenatal fasting glucose, insulin, and insulin resistance during pregnancy in overweight women.

Methods

A cohort of overweight and obese pregnant women (N = 95) was recruited from California. Blood samples were collected during late first or second trimester (median = 16 weeks' gestation; range = 10-24 weeks). Exposures included serum concentrations of polybrominated diphenyl ethers (PBDEs) and hydroxylated metabolites (OH-PBDEs), polyc

SUBMITTER: Mehta SS 

PROVIDER: S-EPMC7855882 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature