Decreased inspired oxygen stimulates de novo formation of coronary collaterals in adult heart.

ABSTRACT:

Rationale

Collateral vessels lessen myocardial ischemia when acute or chronic coronary obstruction occurs. It has long been assumed that although native (pre-existing) collaterals enlarge in obstructive disease, new collaterals do not form in the adult. However, the latter was recently shown to occur after coronary artery ligation. Understanding the signals that drive this process is challenged by the difficulty in studying collateral vessels directly and the complex milieu of signaling pathways, including cell death, induced by ligation. Herein we show that hypoxemia alone is capable of inducing collateral vessels to form and that the novel gene Rabep2 is required.

Objective

Hypoxia stimulates angiogenesis during embryonic development and in pathological states. We hypothes

SUBMITTER: Aghajanian A 

PROVIDER: S-EPMC7855913 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature